<p>The results of experimental study of basaltic melt interaction with different types of sedimentary rocks of the platform shield of the Norilsk region are presented. To study the contamination of basaltic melt with host rocks, the following rocks were used in the experiments: Mokulaev basalt, sandy mudstone, pyrite-bearing sandstone with carbonaceous matter, bituminous dolomite, and marl–anhydrite rock. The experiments were carried out at the Korzhinskii Institute of Experimental Mineralogy of the Russian Academy of Sciences (IEM RAS) in a high-temperature furnace at 1 atm, 1250°C. The phase and chemical composition of the coexisting mineral associations and melts were studied, and geochemical and isotopic data on the starting and experimental products were given. It was found that the contamination of basaltic melt with sulfur- and carbon-bearing rocks of the platform cover of the Norilsk region can lead to silicate–sulfide liquid immiscibility, differentiation, and high ore potential of the trap magma. Results of experimental studies can be used to develop criteria for prospecting and forecasting of sulfide magmatic deposits.</p>