Scholarlink

Abstract <p>The results of the study of dendritic cell (DC) maturation processes generated from CD14<sup>+</sup>monocytes and TCR activation of peripheral blood lymphocytes of 9 Russian crew members of long-term expeditions to the International Space Station (ISS) are presented. It has been shown that human exposure to long-term space flight in low Earth orbit leads to dysfunctions in both DC and T-lymphocytes, as it is evidenced by a decrease in the content of mature DC expressing B7 family co-stimulation molecules and T-lymphocytes expressing CD28 positive co-stimulation molecules. The study revealed an increase in the number of tolerogenic DC with the CD80<sup>+</sup>CD86<sup>–</sup> immunophenotype and T-cells expressing the negative co-stimulation molecule CD152. Against the background of lymphocyte TCR-stimulation in vitro, there were determined changes in processes associated with T-lymphocyte differentiation and synthesis of cytokines. Individual highly variable immune system response to prolonged exposure to the complex factors of space flight was noted.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of Long-Term Space Flight on Human T-Cell Immunity Formation and Development

  • 期刊论文

  • 发表日期：

    2025年12月1日

查看全文
  • O. V. Kutko,
  • M. P. Rykova,
  • E. N. Antropova,
  • V. A. Shmarov,
  • E. A. Zhirova,
  • K. D. Orlova,
  • A. A. Sadova,
  • D. D. Vlasova,
  • S. M. Shulguina,
  • E. A. Lysenko,
  • K. V. Utkin,
  • S. A. Ponomarev

摘要

Abstract

The results of the study of dendritic cell (DC) maturation processes generated from CD14+monocytes and TCR activation of peripheral blood lymphocytes of 9 Russian crew members of long-term expeditions to the International Space Station (ISS) are presented. It has been shown that human exposure to long-term space flight in low Earth orbit leads to dysfunctions in both DC and T-lymphocytes, as it is evidenced by a decrease in the content of mature DC expressing B7 family co-stimulation molecules and T-lymphocytes expressing CD28 positive co-stimulation molecules. The study revealed an increase in the number of tolerogenic DC with the CD80+CD86– immunophenotype and T-cells expressing the negative co-stimulation molecule CD152. Against the background of lymphocyte TCR-stimulation in vitro, there were determined changes in processes associated with T-lymphocyte differentiation and synthesis of cytokines. Individual highly variable immune system response to prolonged exposure to the complex factors of space flight was noted.