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Abstract <p>Urination is a complex physiological process of multilevel regulation, which determines the presence of both individual typological features of this process in healthy young individuals and polypotent symptomatology in case of its disorders, requiring a detailed analysis of intersystem relationships in the implementation of the storage and voiding function of the urinary bladder (UB). Based on the results of current preventive examinations and recommendations of the American Society for Urinary Retention, three groups of young men were identified: with normal (<i>n</i> = 183), borderline (<i>n</i> = 52), and increased (<i>n</i> = 53) urination rhythm (Message 1). In the continuation of the conducted studies, the state of general and regional hemodynamics was additionally assessed at rest. To assess heart rate variability (HRV), a daily computer cardiointervalography (Incart, Russia) was performed with a comparison of the indicators of accumulative and evacuation function of UB in various phases: accumulation and retention of urine (ARU), urge to urinate and during micturition. It was found that with increased urination rate, higher cardiac output and arterial pressure are maintained, but are accompanied by a decrease in blood flow in the detrusor and an increase in vascular resistance. HRV parameters in this group were shifted towards sympathicotonia (increased <i>LF</i> and <i>VLF</i>, decreased <i>HF</i>), whereas vagal influence prevailed in normal rhythm. In addition, individual typological features of the ratio of general hemodynamics and microcirculation in the detrusor were established. Such a complementary approach in studying the indicators of systemic and regional blood circulation, HRV with an assessment of the cumulative and evacuation function of the bladder will make it possible to establish additional mechanisms of intersystem relationships, determine the normative boundaries of urinary parameters necessary in the development of additional criteria for pre-nosological diagnosis and a deeper assessment of disorders of the lower urinary tract.</p>

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System Mechanisms of Urine Formation and Transport. Message 2. Physiological Assessment of the Relationship between Systemic Cardiohemodynamics and Regional Detrusor Blood Flow during the Storage and Voiding Functions of the Bladder in Young Adults with Different Urination Rhythms

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • E. V. Sapozhenkova,
  • V. V. Kolpakov,
  • V. B. Berdichevskii

摘要

Abstract

Urination is a complex physiological process of multilevel regulation, which determines the presence of both individual typological features of this process in healthy young individuals and polypotent symptomatology in case of its disorders, requiring a detailed analysis of intersystem relationships in the implementation of the storage and voiding function of the urinary bladder (UB). Based on the results of current preventive examinations and recommendations of the American Society for Urinary Retention, three groups of young men were identified: with normal (n = 183), borderline (n = 52), and increased (n = 53) urination rhythm (Message 1). In the continuation of the conducted studies, the state of general and regional hemodynamics was additionally assessed at rest. To assess heart rate variability (HRV), a daily computer cardiointervalography (Incart, Russia) was performed with a comparison of the indicators of accumulative and evacuation function of UB in various phases: accumulation and retention of urine (ARU), urge to urinate and during micturition. It was found that with increased urination rate, higher cardiac output and arterial pressure are maintained, but are accompanied by a decrease in blood flow in the detrusor and an increase in vascular resistance. HRV parameters in this group were shifted towards sympathicotonia (increased LF and VLF, decreased HF), whereas vagal influence prevailed in normal rhythm. In addition, individual typological features of the ratio of general hemodynamics and microcirculation in the detrusor were established. Such a complementary approach in studying the indicators of systemic and regional blood circulation, HRV with an assessment of the cumulative and evacuation function of the bladder will make it possible to establish additional mechanisms of intersystem relationships, determine the normative boundaries of urinary parameters necessary in the development of additional criteria for pre-nosological diagnosis and a deeper assessment of disorders of the lower urinary tract.