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Abstract— <p>To increase the number of peptide-based drugs produced, an important task is to reduce the time spent on implementing technological stages. One of the most time-, energy-, and resource-intensive stages of production is vacuum freeze-drying. Therefore, in this work, experimental studies are conducted to select temperature–time regimes for vacuum freeze-drying of peptide-based drugs. As a result of the experiments, a regime is selected that ensures a residual moisture content in the samples of no more than 2.5%, the absence of boiling in the first period of drying, and minimal shrinkage. The work also includes mathematical modeling of the vacuum sublimation drying process using the Comsol Multiphysics software package (calculation of the sublimation front movement in a single H5 bottle).</p>

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Selection of Temperature–Time Modes for Vacuum Freeze-Drying of Peptide-Based Medicinal Preparations

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • E. K. Mokhova,
  • V. S. Derkach,
  • M. G. Gordienko,
  • N. V. Menshutina

摘要

Abstract—

To increase the number of peptide-based drugs produced, an important task is to reduce the time spent on implementing technological stages. One of the most time-, energy-, and resource-intensive stages of production is vacuum freeze-drying. Therefore, in this work, experimental studies are conducted to select temperature–time regimes for vacuum freeze-drying of peptide-based drugs. As a result of the experiments, a regime is selected that ensures a residual moisture content in the samples of no more than 2.5%, the absence of boiling in the first period of drying, and minimal shrinkage. The work also includes mathematical modeling of the vacuum sublimation drying process using the Comsol Multiphysics software package (calculation of the sublimation front movement in a single H5 bottle).