<b>Abstract</b>— <p>Indoor air quality is a pressing issue due to concerns about the health of citizens. One of the new methods of cleaning indoor air is to spray a special adsorbent aerosol. In this work, nanosized TiO₂ and ZnO particles are considered as such absorbents, also having photocatalytic activity. In order to increase the efficiency of neutralization of toxic gases, the work studies the influence of environmental conditions such as humidity, temperature, and atmospheric composition, as well as spray conditions and particle concentration, on this process. Environmental conditions, primarily humidity, influence the dynamics of vapor neutralization. These factors determine both the surface processes on particles and the efficiency of generating active radicals involved in oxidation reactions. In the work the results of a theoretical study of the influence of environmental conditions and particle concentration on the neutralization of toxic gases are presented. An experiment is conducted to purify air from vapors of a model substance (acetone) under various humidity conditions (from 25 to 90%). Spraying is carried out using a pulsed method based on the energy of the VEM in an experimental climatic chamber with a volume of 10 m³. The concentration of acetone vapor in the air is recorded using an IR spectrometer and the size of the aerosol particles is measured using an optical method based on the principle of small-angle scattering. The results show a high degree of adsorption (up to 85% in 1500 s), but at high humidity of about 90% the process rate is slower. Neutralization mechanisms are discussed. The importance of high aerosol dispersion for successful vapor neutralization is emphasized. The results of the work will be used to improve the method of aerosol air purification from toxic vapors and gases.</p>