Abstract <p>Results are presented from studying the adsorption of potential reagent collector 4-(1-naphthylazo)naphthol-1 on chalcopyrite, a monomineral that is a part of copper–nickel sulfide ore. The dependence of adsorption on the pH of the solution has been determined, along with the kinetic and thermodynamic parameters of adsorption at 296, 299, 302, 305, and 315 K. The rate constants of reagent adsorption on chalcopyrite have been calculated for pseudo-first and pseudo-second order equations. Adsorption isotherms at all studied temperatures have been constructed in the coordinates of the Langmuir and Freundlich equations, and the constants of each model have been determined. Changes in enthalpy, entropy, and the Gibbs free energy have been calculated using Langmuir adsorption constants for different temperatures. The obtained values of thermal effects show that the adsorption of 4-(1-naphthylazo)naphthol-1 on the surface of chalcopyrite is due mainly to chemisorption. Positive enthalpy and negative Gibbs energies indicate endothermic and spontaneous adsorption. The contact angles of wetting on the surface of chalcopyrite have been determined before and after treating it with a solution of 4-(1-naphthylazo)naphthol-1. It was established that the reagent had the highest hydrophobic capacity for chalcopyrite at pH 10.0.</p>