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Abstract <p>The interactions of the polar basic amino acid L-lysine (Lys) with the structural isomers of pyridine monocarboxylic acid: picolinic (PA), nicotinic (NA), and isonicotinic (INA) acids in aqueous solution were studied by solution calorimetry at 298.15 K. The experimental data allowed us to establish the formation of 1&#xa0;:&#xa0;1 complexes of Lys with the indicated isomers. The thermodynamic parameters were determined: binding constants, enthalpies of complexation, Gibbs energies, and entropies. The stability of the obtained complexes depends on the structural isomerism of pyridine carboxylic acid and increases in the series: PA &lt; NA&#xa0;&lt; INA. The main contribution to the stabilization of the complexes is from the enthalpy component of the Gibbs free energy of complexation.</p>

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Thermodynamic Characteristics of L-Lysine Complexation with Pyridine Monocarboxylic Acid Isomers in Aqueous Solution

  • 期刊论文

  • 发表日期：

    2025年9月16日

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  • E. Yu. Tyunina,
  • I. N. Mezhevoi

摘要

Abstract

The interactions of the polar basic amino acid L-lysine (Lys) with the structural isomers of pyridine monocarboxylic acid: picolinic (PA), nicotinic (NA), and isonicotinic (INA) acids in aqueous solution were studied by solution calorimetry at 298.15 K. The experimental data allowed us to establish the formation of 1 : 1 complexes of Lys with the indicated isomers. The thermodynamic parameters were determined: binding constants, enthalpies of complexation, Gibbs energies, and entropies. The stability of the obtained complexes depends on the structural isomerism of pyridine carboxylic acid and increases in the series: PA < NA < INA. The main contribution to the stabilization of the complexes is from the enthalpy component of the Gibbs free energy of complexation.