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Abstract <p>Here, we prepared a number of quinoline-2-carboxylic acid or quinoxaline-2-carboxylic acid amino acid esters derivatives with aromatic and aliphatic terminal groups (Qln-Ser-OMe, Qln-Thr-OMe, Qox-Thr-OMe, and Qox-Trp-OMe). Compounds were characterized by IR, NMR spectroscopies and MS spectrometry. Silver(I) complexes with the organic ligands of the general form [AgL<sub>2</sub>]NO<sub>3</sub> were prepared in order to increase their water solubility. The structures of compounds Qox-Trp-OMe and [AgL<sub>2</sub>]NO<sub>3</sub> (L = Qln-Ser-OMe) were determined by single-crystal X-ray diffraction. The proposed compounds in the form of water-soluble silver(I) nitrate complexes were found to be effective in suppressing the reproduction of the rimantadine-resistant influenza virus strain A/IIV-Orenburg/83/2012(H1N1)pdm09 in experiments in vitro using a MDCK cell culture model.</p>

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Silver(I) Complexes Based on 2-Quinoline or 2-Quinoxaline Derivatives of Amino Acid Esters as New Antiviral Drugs

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • T. M. Garaev,
  • I. I. Yudin,
  • N. V. Breslav,
  • T. V. Grebennikova,
  • A. S. Kubasov,
  • V. V. Avdeeva,
  • L. V. Goeva,
  • A. V. Golubev,
  • S. E. Nikiforova,
  • E. A. Malinina

摘要

Abstract

Here, we prepared a number of quinoline-2-carboxylic acid or quinoxaline-2-carboxylic acid amino acid esters derivatives with aromatic and aliphatic terminal groups (Qln-Ser-OMe, Qln-Thr-OMe, Qox-Thr-OMe, and Qox-Trp-OMe). Compounds were characterized by IR, NMR spectroscopies and MS spectrometry. Silver(I) complexes with the organic ligands of the general form [AgL2]NO3 were prepared in order to increase their water solubility. The structures of compounds Qox-Trp-OMe and [AgL2]NO3 (L = Qln-Ser-OMe) were determined by single-crystal X-ray diffraction. The proposed compounds in the form of water-soluble silver(I) nitrate complexes were found to be effective in suppressing the reproduction of the rimantadine-resistant influenza virus strain A/IIV-Orenburg/83/2012(H1N1)pdm09 in experiments in vitro using a MDCK cell culture model.