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Abstract <p>The reaction of 2-oxo-4<i>H</i>-pyran-2,6-dicarboxylic (chelidonic) acid with magnesium acetate afforded cocrystalline compound, magnesium chelidonate. The study of thermooxidative destruction of magnesium chelidonate have shown that its dehydration proceeds in two stages, while thermal destruction of organic moiety is accompanied by pronounced thermal effects. The structure of magnesium chelidonate consists of inner and outer coordination spheres around magnesium cation. The inner sphere includes six water molecules that form hexaaqua magnesium cation. The outer sphere is formed by the anions of chelidonic acid associated by hydrogen bonds with water molecules in the inner coordination sphere of magnesium cation. The structure of magnesium chelidonate crystallizes in triclinic syngony, space group <i>P</i><InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="11502_2025_3647_Article_IEq1.gif" Format="GIF" Height="16" Rendition="HTML" Resolution="72" Type="Linedraw" Width="10" /> </InlineMediaObject> <EquationSource Format="TEX">\(\bar {1}\)</EquationSource> <!--InrgChem2460307Kozin-m1--> </InlineEquation>, and has extended network of hydrogen bonds between coordinated water molecules, acid anions, and hexaaqua magnesium cations. The comparative analysis of neuroprotective activity of magnesium chelidonate and chelidonic acid showed that both compounds protect cultivated neurons in the model of cellular ischemia. This effect is expressed by decrease of neuron death upon oxygen–glucose deprivation. Magnesium chelidonate was more efficient than chelidonic acid at the same concentrations.</p>

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Synthesis and Physicochemical Properties of Magnesium Salts of 4H-Pyrancarboxylic Acids

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • S. V. Kozin,
  • A. A. Kravtsov,
  • V. K. Kindop,
  • A. V. Bespalov,
  • L. I. Ivaschenko,
  • M. A. Nazarenko,
  • A. V. Moiseev,
  • A. V. Churakov,
  • A. S. Vashurin

摘要

Abstract

The reaction of 2-oxo-4H-pyran-2,6-dicarboxylic (chelidonic) acid with magnesium acetate afforded cocrystalline compound, magnesium chelidonate. The study of thermooxidative destruction of magnesium chelidonate have shown that its dehydration proceeds in two stages, while thermal destruction of organic moiety is accompanied by pronounced thermal effects. The structure of magnesium chelidonate consists of inner and outer coordination spheres around magnesium cation. The inner sphere includes six water molecules that form hexaaqua magnesium cation. The outer sphere is formed by the anions of chelidonic acid associated by hydrogen bonds with water molecules in the inner coordination sphere of magnesium cation. The structure of magnesium chelidonate crystallizes in triclinic syngony, space group P \(\bar {1}\) , and has extended network of hydrogen bonds between coordinated water molecules, acid anions, and hexaaqua magnesium cations. The comparative analysis of neuroprotective activity of magnesium chelidonate and chelidonic acid showed that both compounds protect cultivated neurons in the model of cellular ischemia. This effect is expressed by decrease of neuron death upon oxygen–glucose deprivation. Magnesium chelidonate was more efficient than chelidonic acid at the same concentrations.