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<b>Abstract</b>— <p>The conjugative plasmid pD4A-46, belonging to the P-7 incompatibility group, obtained from an environmental <i>Pseudomonas fluorescens</i> strain, confers tetracycline resistance to the host cells. However, no known tetracycline resistance genes were found in pD4A-46. Potential tetracycline resistance determinants within the pD4A-46 plasmid were investigated by analyzing the expression levels in <i>P. putida</i> KT2442 (pD4A-46) cells grown with and without tetracycline. The results of this analysis identified putative genes that function as tetracycline resistance determinants.</p>

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A P-7 Incompatibility Group Plasmid Controls Non-Specific Tetracycline Resistance of the Host Strain

  • 期刊论文

  • 发表日期：

    2026年5月25日

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  • T. Yu. Izmalkova,
  • I. E. Granovsky,
  • O. I. Sazonova,
  • S. L. Sokolov,
  • I. A. Kosheleva

摘要

Abstract—

The conjugative plasmid pD4A-46, belonging to the P-7 incompatibility group, obtained from an environmental Pseudomonas fluorescens strain, confers tetracycline resistance to the host cells. However, no known tetracycline resistance genes were found in pD4A-46. Potential tetracycline resistance determinants within the pD4A-46 plasmid were investigated by analyzing the expression levels in P. putida KT2442 (pD4A-46) cells grown with and without tetracycline. The results of this analysis identified putative genes that function as tetracycline resistance determinants.