Scholarlink

<b>Abstract</b>— <p>This is the first report on combined inhibitory effect of the hormone estradiol and the antibiotic tetracycline on the type strain <i>Staphylococcus aureus</i> 209 P<sup>T</sup>. Combined application of the hormone and antibiotic resulted in a significantly increased doubling time compared to the samples treated with tetracycline alone (0.05 µg/mL). While the combined effect was more pronounced against initial growth stages of planktonic cultures, it also occurred in the case of biofilms. In almost all cases the highest effect of estradiol was found at its concentrations one or two orders of magnitude exceeding the physiological one (2.2 × 10<sup>−10</sup> M).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of Estradiol on In Vivo Tetracycline Sensitivity of Staphylococcus aureus 209P

  • 期刊论文

  • 发表日期：

    2025年9月17日

查看全文
  • N. A. Loginova,
  • A. A. Metkina,
  • A. V. Gannesen,
  • S. V. Mart’yanov

摘要

Abstract—

This is the first report on combined inhibitory effect of the hormone estradiol and the antibiotic tetracycline on the type strain Staphylococcus aureus 209 PT. Combined application of the hormone and antibiotic resulted in a significantly increased doubling time compared to the samples treated with tetracycline alone (0.05 µg/mL). While the combined effect was more pronounced against initial growth stages of planktonic cultures, it also occurred in the case of biofilms. In almost all cases the highest effect of estradiol was found at its concentrations one or two orders of magnitude exceeding the physiological one (2.2 × 10−10 M).