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<b>Abstract</b>— <p>Biosynthetic gene clusters (BGCs) for the biosynthesis of secondary metabolites in <i>Pseudogymnoascus</i> spp. strains were analyzed using the antiSMASH software (fungal version). This is the first report on the <i>Pseudogymnoascus</i> genomes containing several dozen BGCs for secondary metabolite biosynthesis. Approximately 30% of these consisted of gene clusters for the biosynthesis of known metabolites, with similarity ranging from 9 to 100%. Cultivation of eight <i>Pseudogymnoascus</i> spp. strains in mineral medium revealed 13 metabolites. In five strains, 3–4 compounds were detected, and three strains synthesized the siderophore desferritriacetylfusigen. The secondary metabolites synthesized by <i>Pseudogymnoascus</i> spp. strains were shown to possess potential biological activity. The highest antibacterial, antifungal, phytotoxic, and entomotoxic activities were observed in the secondary metabolites of strains VKM F-4513 and F-4517, isolated from Arctic permafrost deposits.</p>

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Metabolic Potential of Pseudogymnoascus spp. Fungi

  • 期刊论文

  • 发表日期：

    2025年9月17日

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  • T. V. Antipova,
  • V. P. Zhelifonova,
  • V. R. Dubovik,
  • E. G. Lukina,
  • Q. Hu,
  • G. A. Kochkina,
  • A. O. Berestetskiy

摘要

Abstract—

Biosynthetic gene clusters (BGCs) for the biosynthesis of secondary metabolites in Pseudogymnoascus spp. strains were analyzed using the antiSMASH software (fungal version). This is the first report on the Pseudogymnoascus genomes containing several dozen BGCs for secondary metabolite biosynthesis. Approximately 30% of these consisted of gene clusters for the biosynthesis of known metabolites, with similarity ranging from 9 to 100%. Cultivation of eight Pseudogymnoascus spp. strains in mineral medium revealed 13 metabolites. In five strains, 3–4 compounds were detected, and three strains synthesized the siderophore desferritriacetylfusigen. The secondary metabolites synthesized by Pseudogymnoascus spp. strains were shown to possess potential biological activity. The highest antibacterial, antifungal, phytotoxic, and entomotoxic activities were observed in the secondary metabolites of strains VKM F-4513 and F-4517, isolated from Arctic permafrost deposits.