Abstract <p>Soil contamination with heavy metals is a major worldwide problem due to their persistent non-biodegradable toxic nature. Heavy metal pollution of soil occurs because of activities such as mining, metal smelting, and car battery manufacture. The persistence of heavy metals in the environment poses severe ecological and health risks, including bioaccumulation in aquatic organisms and adverse effects on plant growth and soil microorganisms. Human exposure to heavy metals results in respiratory problems, skin disorders, and heightened cancer risk. Addressing these challenges necessitates sustainable remediation approaches, highlighting the potential of biosurfactants as eco-friendly alternatives to conventional methods. Biosurfactants as microbial-derived surface-active agents exhibit properties that make them highly effective in decreasing heavy metals contamination. Their amphiphilic nature enhances heavy metals bioavailability and facilitates their removal. Moreover, their biodegradability, economic efficacy, low toxicity, and renewable production ensure minimal environmental impact. This review aims to discuss various properties of biosurfactants and their application in the bioremediation of heavy metals from contaminated environments. The study also includes the mechanisms of biosurfactants interaction with heavy metals that enhance their application in diverse environmental conditions.</p>