Abstract <p>Lattice structures are employed in the aerospace, automotive, and medical industries due to their high energy absorption, high porosity, and high strength-to-density ratios. Besides the traditional manufacturing approach, here we employed additive manufacturing, Fused deposition modeling (FDM) approach. In this paper, effect of struts on compressive deformation behavior of Body-centered cubic (BCC), Helix body-centered cubic (HBCC), Half vertical strut body-centered cubic (HVSBCC) and Full vertical strut body center cubic (FVSBCC) structures are examined both numerically and experimentally. The results show that the half verticle strut body center cubic has superior properties. The compressive strength of the Half vertical strut body-centered cubic (9.5 MPa) is ~436.72% higher than simple body-centered cubic (1.77 MPa), ~139.89% higher than the helix body-centered cubic ( 3.96 MPa), and ~25% higher than full vertical strut body-centered cubic (7.6 MPa). Also, The energy absorption of half vertical strut body-centered (3.49 MJ/m³) is ~14817.39% higher than the simple body-centered cubic (0.23 MJ/m³), ~711.62% higher than the helix simple cubic (0.43MJ/m³) and ~36.8% higher than the full vertical strut body-centered cubic. Further, the strut variation among structures controls the Poisson ratio and ultimately the strain-induced deformation response. Hence, optimizing local strut alignments in the lattice structures guides to betterment of mechanical properties for varied applications.</p>