Abstract <p>This article investigates the thermoelastic responses of living tissues under thermal loading, considering the Green and Naghdi theory with and without energy dissipation in hyperthermia treatment. A thorough understanding of the bioheat transfer mechanisms and associated thermomechanical interactions within living tissues is essential for effectively applying thermal treatment techniques. The study models the surface of living tissues as free of traction and subjected to an exponentially decaying pulsed boundary heat flux. The generalized Biothermoelastic model is analyzed using Laplace transforms and eigenvalues approach to get the analytical solutions of governing equations. The displacement, temperature, and stress results are presented graphically, followed by a parametric study to determine optimal design parameters that can improve the accuracy and efficiency of thermal therapy treatments.</p>