Abstract <p>The kinetics of tetrahydrofuran oxidation in aqueous solution initiated by 2,2'-azobis(2-amidinopropane) dihydrochloride were studied. The reaction rate was monitored by oxygen uptake using the manometric method. The initiation rate constant of water-soluble 2,2'-azobis(2-amidinopropane) dihydrochloride was determined within the range 303–323 K: log <i>k</i>_i = (11.9 ± 0.6) – (104.8 ± 4.3)/θ [s^–1], θ = 2.303<i>RT</i> kJ/mol. The rate of tetrahydrofuran oxidation (w) was found to depend linearly on its concentration. A quadratic dependence of w on the initiator concentration was observed. The values of <i>k</i>₂(2<i>k</i>₆)^–0.5 (oxidation parameter) for tetrahydrofuran oxidation were obtained. In Arrhenius coordinates, this parameter is expressed as log (<i>k</i>₂(2<i>k</i>₆)^–0.5) = (2.8 ± 0.1) – (36.1 ± 0.7)/θ [L^0.5 mol^–0.5 s^–0.5], θ = 2.303<i>RT</i> kJ/mol. The rate constants for the reactions of tetrahydrofuran peroxyl radicals with α-tocopherol and with 2,2,5,7,8-pentamethyl-6-chromanol in aqueous medium were determined as (2.0 ± 0.3) × 10⁵ L mol^–1 s^–1 (303–318 K) and (2.8 ± 0.5) × 10⁵ L mol^–1 s^–1 (309 K), respectively.</p>