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Abstract <p>Crystals suitable for the single crystal X-ray diffraction (XRD) analysis oxcarbazepine (OxCBZ) solvate with chloroform are grown for the first time. A procedure is proposed to reproducibly obtain this solvate. The crystal structure solution enables the determination of the main types of intermolecular interactions stabilizing the molecular packing. The powder XRD analysis shows that during desolvation new unstable phases form, which are prone to transformation to thermodynamically stable I polymorph OxCBZ.</p>

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New Oxcarbazepine Solvate(10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide) with Chloroform: Crystallization, Stability, and Crystal Structure Analysis

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • D. Ya. Zheltikova,
  • E. A. Losev,
  • E. V. Boldyreva

摘要

Abstract

Crystals suitable for the single crystal X-ray diffraction (XRD) analysis oxcarbazepine (OxCBZ) solvate with chloroform are grown for the first time. A procedure is proposed to reproducibly obtain this solvate. The crystal structure solution enables the determination of the main types of intermolecular interactions stabilizing the molecular packing. The powder XRD analysis shows that during desolvation new unstable phases form, which are prone to transformation to thermodynamically stable I polymorph OxCBZ.