Scholarlink

Abstract <p>The study investigated changes in nitroxidergic system activityin white rats exposed to forced physical exercise under conditionsof normal motor activity and hypokinesia relative to the level of iodothyroninesproduction. The experiment was carried out on 8 groups of animals:control; euthyroid rats exposed to forced swim; euthyroid rats exposed tohypokinesia; euthyroid rats exposed to forced swim following a 7-dayhypokinesia; hypothyroid rats with thiamazole-induced hypothyroidism; hypothyroidrats exposed to forced swim; hypothyroid rats exposed to hypokinesia;hypothyroid rats exposed to forced swim following a 7-day hypokinesia.It was found that euthyroid rats with normal motor activity, exposedto forced physical exercise, are characterized by an increase inserum nitrite concentration. Forced physical exercise against the backgroundof preceding hypokinesia in euthyroid rats causes a shift in theactivity of the thyroid axis and the nitroxidergic system, whichmanifests as decreased iodothyronines levels, increased asymmetricdimethylarginine (ADMA) concentration, with no increase in serumnitrite concentration. Serum nitrite levels in euthyroid animalsare directly dependent on thyroxine concentration and inversely dependenton ADMA concentration. Thiamazole-induced restriction of iodothyroninesproduction enhances the negative effect of hypokinesia on the functioningof the nitroxidergic system under forced physical exercise, whichmanifests as a more pronounced increase in ADMA concentration. Furthermore,when iodothyronines production is blocked, serum nitrite levelsincrease significantly relative to control values, while not changingunder the influence of hypokinesia, forced physical exercise, or theircombination. Blockade of iodothyronines production alters the patternof correlative interrelations both between the parameters of thyroidaxis activity and the nitroxidergic system and between metabolite concentrationsof the nitroxidergic system. The obtained results indicate a relationshipbetween the thyroid regulatory axis and the nitroxidergic system duringrat adaptation to different levels of physical activity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Interrelation between Thyroid Hormone Production and Changes in the Nitroxidergic System under Different Modes of Physical Activity in White Rats

  • 期刊论文

  • 发表日期：

    2026年6月21日

查看全文
  • A. N. Ivanov,
  • A. N. Golubeva,
  • N. B. Shestopalova,
  • T. S. Kiriazi,
  • A. N. Zorkin

摘要

Abstract

The study investigated changes in nitroxidergic system activityin white rats exposed to forced physical exercise under conditionsof normal motor activity and hypokinesia relative to the level of iodothyroninesproduction. The experiment was carried out on 8 groups of animals:control; euthyroid rats exposed to forced swim; euthyroid rats exposed tohypokinesia; euthyroid rats exposed to forced swim following a 7-dayhypokinesia; hypothyroid rats with thiamazole-induced hypothyroidism; hypothyroidrats exposed to forced swim; hypothyroid rats exposed to hypokinesia;hypothyroid rats exposed to forced swim following a 7-day hypokinesia.It was found that euthyroid rats with normal motor activity, exposedto forced physical exercise, are characterized by an increase inserum nitrite concentration. Forced physical exercise against the backgroundof preceding hypokinesia in euthyroid rats causes a shift in theactivity of the thyroid axis and the nitroxidergic system, whichmanifests as decreased iodothyronines levels, increased asymmetricdimethylarginine (ADMA) concentration, with no increase in serumnitrite concentration. Serum nitrite levels in euthyroid animalsare directly dependent on thyroxine concentration and inversely dependenton ADMA concentration. Thiamazole-induced restriction of iodothyroninesproduction enhances the negative effect of hypokinesia on the functioningof the nitroxidergic system under forced physical exercise, whichmanifests as a more pronounced increase in ADMA concentration. Furthermore,when iodothyronines production is blocked, serum nitrite levelsincrease significantly relative to control values, while not changingunder the influence of hypokinesia, forced physical exercise, or theircombination. Blockade of iodothyronines production alters the patternof correlative interrelations both between the parameters of thyroidaxis activity and the nitroxidergic system and between metabolite concentrationsof the nitroxidergic system. The obtained results indicate a relationshipbetween the thyroid regulatory axis and the nitroxidergic system duringrat adaptation to different levels of physical activity.