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Abstract <p>To ensure adequate tissue perfusion, along with a properlyfunctioning endothelium that enables vasodilation, the rheologicalproperties of blood, such as hematocrit, blood viscosity, erythrocyte(RBC) deformability and aggregation, are important components ofthe circulatory system. Experiments on Sprague–Dawley rats aged4, 18, and 23 months have shown that with age, hematocrit decreases, plasmaand blood viscosity increase, and the degree of RBC aggregationrises. The RBC deformability index also significantly increases,indicating a decline in cell deformability. Along with age-related changesin blood rheological properties, an increase in desquamated endothelialcell count was observed in the blood plasma, indicating endothelialdysfunction. Overall, such changes lead to impaired microcirculation.The age-related changes in blood rheological parameters, as recordedin our study, are consistent with the results of cerebral cortexperfusion using Doppler ultrasonography and indicate a deteriorationin microcirculation. Rheological parameters, such as blood viscosity,the degree of RBC aggregation, and their deformability index, in ratschange as early as 18 months of age and can serve as markers ofage-related changes in healthy animals.</p>

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Blood Rheological Properties in Rats of Different Ages

  • 期刊论文

  • 发表日期：

    2026年6月21日

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  • V. N. Shuvaeva,
  • O. P. Gorshkova

摘要

Abstract

To ensure adequate tissue perfusion, along with a properlyfunctioning endothelium that enables vasodilation, the rheologicalproperties of blood, such as hematocrit, blood viscosity, erythrocyte(RBC) deformability and aggregation, are important components ofthe circulatory system. Experiments on Sprague–Dawley rats aged4, 18, and 23 months have shown that with age, hematocrit decreases, plasmaand blood viscosity increase, and the degree of RBC aggregationrises. The RBC deformability index also significantly increases,indicating a decline in cell deformability. Along with age-related changesin blood rheological properties, an increase in desquamated endothelialcell count was observed in the blood plasma, indicating endothelialdysfunction. Overall, such changes lead to impaired microcirculation.The age-related changes in blood rheological parameters, as recordedin our study, are consistent with the results of cerebral cortexperfusion using Doppler ultrasonography and indicate a deteriorationin microcirculation. Rheological parameters, such as blood viscosity,the degree of RBC aggregation, and their deformability index, in ratschange as early as 18 months of age and can serve as markers ofage-related changes in healthy animals.