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Abstract <p>The review addresses the mechanisms of activation of purinergicregulation of signaling processes in skeletal muscles during theirunloading. A special focus is on their involvement in the regulationof calcium homeostasis in muscle fibers. We believe that changesin the membrane potential of muscle fibers and ATP levels (whichincrease during the first days of unloading) trigger the activationof purinergic receptors and the appropriate signaling, which is involvedin initiating muscle atrophy. We hypothesize that there is an interrelationshipbetween functional changes in Na,K-ATPase, dihydropyridine receptors,pannexin channels, and P2Y1/2 receptors, on the one hand, and theactivation of PI3K- and IP3-dependent signaling, on the other hand.We assume that these components are closely linked to the regulationof ATP and calcium levels in muscle fibers during their functionalunloading.</p>

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Mechanisms of Purinergic Regulation of Signaling Processes in Skeletal Muscles during Their Unloading

  • 期刊论文

  • 发表日期：

    2026年6月21日

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  • T. L. Nemirovskaya

摘要

Abstract

The review addresses the mechanisms of activation of purinergicregulation of signaling processes in skeletal muscles during theirunloading. A special focus is on their involvement in the regulationof calcium homeostasis in muscle fibers. We believe that changesin the membrane potential of muscle fibers and ATP levels (whichincrease during the first days of unloading) trigger the activationof purinergic receptors and the appropriate signaling, which is involvedin initiating muscle atrophy. We hypothesize that there is an interrelationshipbetween functional changes in Na,K-ATPase, dihydropyridine receptors,pannexin channels, and P2Y1/2 receptors, on the one hand, and theactivation of PI3K- and IP3-dependent signaling, on the other hand.We assume that these components are closely linked to the regulationof ATP and calcium levels in muscle fibers during their functionalunloading.