Abstracts <p>Cardiovascular diseases remain the leading cause of globalmortality, and their most severe manifestations are associated withmyocardial injury. Therefore, strategies aimed at limiting primarymyocardial injury and regulating remodeling processes are a criticallyimportant approach in modern cardiology. In recent years, researchfocus has been on regulatory peptides possessing systemic protectiveand reparative potential. The aim of this study was to evaluate thepossible cardioprotective properties of synthetic rat obestatinin in vivo studies using electro- and echocardiography in a modelof myocardial injury induced by the β-adrenomimetic in rats. Itwas shown that obestatin pre-administration in a model of isoproterenol-inducedmyocardial injury completely prevents acute lethality, acceleratesthe recovery of physiological vegetative balance by normalizingheart rate variability parameters, and alters the pattern of leftventricular structural remodeling, shifting it toward a more adaptiveeccentric dilation pattern. The cardioprotective effect of obestatinmay be attributed to its normalizing effect on isoproterenol-inducedprolongation of RR intervals and QRS complex, reflecting impairedintraventricular conduction.</p>