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Abstract <p>Inflammation is an important link in the pathogenesis of numerouspathological conditions, including neurodegenerative diseases. Theeffects of experimental systemic inflammation on intercellular interactionsin the central nervous system are widely studied, while reactivechanges caused by the administration of lipopolysaccharide (LPS)in the organs of the peripheral nervous system, including dorsalroot ganglia, are investigated less intensively. The aim of thisstudy was to evaluate reactive morphofunctional alterations in satelliteglial cells (SGCs) and macrophages of the rat dorsal root gangliain response to experimental systemic inflammation. For immunohistochemicaldetection of macrophages, antibodies to the Iba-1 protein were used;as an immunohistochemical marker of activated SGCs, antibodies toglial fibrillary acidic protein (GFAP) were applied. The obtainedresults indicate a dose-dependent activation of SGCs and macrophages:a higher LPS dose activates SGCs to a greater extent, while a lowerLPS dose leads to more intensive macrophage activation.</p>

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Responses of Macrophages and Satellite Glial Cells in Rat Dorsal Root Ganglia to Parenteral Administration of Bacterial Lipopolysaccharide

  • 期刊论文

  • 发表日期：

    2026年2月26日

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  • E. A. Kolos,
  • D. E. Korzhevskii

摘要

Abstract

Inflammation is an important link in the pathogenesis of numerouspathological conditions, including neurodegenerative diseases. Theeffects of experimental systemic inflammation on intercellular interactionsin the central nervous system are widely studied, while reactivechanges caused by the administration of lipopolysaccharide (LPS)in the organs of the peripheral nervous system, including dorsalroot ganglia, are investigated less intensively. The aim of thisstudy was to evaluate reactive morphofunctional alterations in satelliteglial cells (SGCs) and macrophages of the rat dorsal root gangliain response to experimental systemic inflammation. For immunohistochemicaldetection of macrophages, antibodies to the Iba-1 protein were used;as an immunohistochemical marker of activated SGCs, antibodies toglial fibrillary acidic protein (GFAP) were applied. The obtainedresults indicate a dose-dependent activation of SGCs and macrophages:a higher LPS dose activates SGCs to a greater extent, while a lowerLPS dose leads to more intensive macrophage activation.