Scholarlink

Abstract <p>The study evaluates the impact of partial sleep deprivationfor 4 weeks on the outcome of myocardial ischemic injury in agedfemale rats. Sleep-deprivation was performed by insomnia 5 days/weekfor 4 weeks, then myocardial infarction was induced in aged femalerats (24–26 months) by isoproterenol injection. Induction of insomniain myocardial infarcted rats showed a significant worsening in the valuesof electrocardiography, mean blood pressure, and contractility indices.This group exhibited significantly higher levels of serum cardiactroponin I, glucose, and insulin, increased insulin resistance and dyslipidemia,significantly elevated aortic tissue oxidative and inflammatorymarkers, endothelial dysfunction, and decreases in the aortic tissuelevels of BCL2. This suggests that insomnia in elderly women couldexacerbate the progression of ischemic heart diseases, such as anginapectoris and myocardial infarction. The underlying mechanisms mayinvolve endothelial dysfunction and metabolic syndrome.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Sleep Deprivation Impairs Endothelial Markers and Exacerbates Myocardial Ischemic Injury in Aged Female Rats

  • 期刊论文

  • 发表日期：

    2026年4月19日

查看全文
  • Nehal Mohamed Bahgat,
  • Samar M. M. Abd El Rahman,
  • Mohamed Hassan ElSayed,
  • Ghada Galal Hamam,
  • Reham Hussein Mohamed,
  • A. E. El-Sebaiee

摘要

Abstract

The study evaluates the impact of partial sleep deprivationfor 4 weeks on the outcome of myocardial ischemic injury in agedfemale rats. Sleep-deprivation was performed by insomnia 5 days/weekfor 4 weeks, then myocardial infarction was induced in aged femalerats (24–26 months) by isoproterenol injection. Induction of insomniain myocardial infarcted rats showed a significant worsening in the valuesof electrocardiography, mean blood pressure, and contractility indices.This group exhibited significantly higher levels of serum cardiactroponin I, glucose, and insulin, increased insulin resistance and dyslipidemia,significantly elevated aortic tissue oxidative and inflammatorymarkers, endothelial dysfunction, and decreases in the aortic tissuelevels of BCL2. This suggests that insomnia in elderly women couldexacerbate the progression of ischemic heart diseases, such as anginapectoris and myocardial infarction. The underlying mechanisms mayinvolve endothelial dysfunction and metabolic syndrome.