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Abstract <p>An original model of a flow system simulating the hemodynamicprocess in capillaries was created to study neutrophil migration.Using this model, it was found that the general neutrophil migratorypatterns (aggregate and tether formation, migration along intercellularcontacts of endothelial cells) are reproduced both in the control(a system without chemoattractants) and in the experiment (a system withlow-molecular-weight bacterial chemoattractants). However, when <i>S. aureus</i> and <i>P.&#xa0;mirabilis</i> wereused as chemoattractants, the number of aggregates and neutrophiltethers increased statistically significantly (<i>p</i> &lt;0.05). The aggregates correspond to the swarming phenomenon in thetransendothelial migration system and contribute to limiting thezone of bacterial infection. The neutrophil tethers slow down thehemodynamic movement of cells and can either trigger migration orserve as precursors for the formation of elongated neutrophil-derivedstructures with a high antibacterial potential. Thus, all the observedphenomena promote the implementation of protective functions inthe case of bacteremia.</p>

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The Peculiarities of Neutrophil Migration in the Flow System

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • S. N. Pleskova,
  • N. A. Bezrukov,
  • E. N. Gorshkova,
  • D. V. Novikov,
  • E. V. Otstavnova

摘要

Abstract

An original model of a flow system simulating the hemodynamicprocess in capillaries was created to study neutrophil migration.Using this model, it was found that the general neutrophil migratorypatterns (aggregate and tether formation, migration along intercellularcontacts of endothelial cells) are reproduced both in the control(a system without chemoattractants) and in the experiment (a system withlow-molecular-weight bacterial chemoattractants). However, when S. aureus and P. mirabilis wereused as chemoattractants, the number of aggregates and neutrophiltethers increased statistically significantly (p <0.05). The aggregates correspond to the swarming phenomenon in thetransendothelial migration system and contribute to limiting thezone of bacterial infection. The neutrophil tethers slow down thehemodynamic movement of cells and can either trigger migration orserve as precursors for the formation of elongated neutrophil-derivedstructures with a high antibacterial potential. Thus, all the observedphenomena promote the implementation of protective functions inthe case of bacteremia.