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Abstract <p>The aim of the study was to investigate the functional roleof the TAAR1 receptor in the formation of the stress response behavioralcomponent. The behavior of TAAR1 knockout (TAAR1-KO) and wild-type(WT) mice was studied in tests reflecting a depressive-like statebefore and after chronic stress exposure (predator stress model),as well as delayed behavioral changes six weeks later. In the tail suspensiontest and the Porsolt forced swim test, no differences in depressive-likebehavior were observed between TAAR1-KO and WT mice, either undernormal conditions or after chronic stress exposure. However, TAAR1-KOmice exhibited motor hyperactivity at the onset of testing whenplaced in a stressful situation, leading to a sharp increase inthe latency to first immobility in both tests. TAAR1 knockout didnot affect signs of depressive-like behavior but led to a characteristicincrease in motor activity levels. TAAR1-KO mice demonstrated amore pronounced response to chronic stress, with slower body weightrecovery after stress cessation, such that their body weight remainedsignificantly lower than that of WT mice for the last five weeks.It was found that six weeks after stress exposure, the indices ofa depressive-like state continued to increase in both TAAR1-KO andWT mice.</p>

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Effect of Chronic Stress on TAAR1 Knockout Mice Tested for Depressive-like Behavior

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • E. P. Vinogradova,
  • A. Yu. Aleksandrov,
  • D. V. Belyakov,
  • E. S. Dmitrieva,
  • L. N. Stankevich,
  • A. A. Aleksandrov

摘要

Abstract

The aim of the study was to investigate the functional roleof the TAAR1 receptor in the formation of the stress response behavioralcomponent. The behavior of TAAR1 knockout (TAAR1-KO) and wild-type(WT) mice was studied in tests reflecting a depressive-like statebefore and after chronic stress exposure (predator stress model),as well as delayed behavioral changes six weeks later. In the tail suspensiontest and the Porsolt forced swim test, no differences in depressive-likebehavior were observed between TAAR1-KO and WT mice, either undernormal conditions or after chronic stress exposure. However, TAAR1-KOmice exhibited motor hyperactivity at the onset of testing whenplaced in a stressful situation, leading to a sharp increase inthe latency to first immobility in both tests. TAAR1 knockout didnot affect signs of depressive-like behavior but led to a characteristicincrease in motor activity levels. TAAR1-KO mice demonstrated amore pronounced response to chronic stress, with slower body weightrecovery after stress cessation, such that their body weight remainedsignificantly lower than that of WT mice for the last five weeks.It was found that six weeks after stress exposure, the indices ofa depressive-like state continued to increase in both TAAR1-KO andWT mice.