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Abstract <p>The endogenous circadian oscillator, located in the mammaliansuprachiasmatic nucleus (SCN), generates its own rhythm, the periodof which typically does not precisely match the 24-h duration ofa day and hence requires entrainment with the geophysical circadianrhythm of the external world. One of the most important non-photicmechanisms of circadian clock entrainment is based on the information aboutthe pattern and intensity of physical activity. Within this mechanism,the role of the key molecular entrainment factor is attributed tothe myokine irisin. Meanwhile, irisin effects on behavioral circadian rhythmsremain unexplored. In the present study, the effects of triple intranasaladministration of irisin (0.5 µg) at various projected time pointsacross three consecutive circadian cycles (ZT 2, ZT 6, ZT 10, ZT14, ZT 18, and ZT 22) on the circadian rhythm of voluntary locomotoractivity in a running wheel under conditions of constant darknesswere investigated for the first time in experiments on male Wistar rats.Irisin administration at ZT 6 led to a statistically significantadvanced phase shift of the rhythm’s acrophase median by 0.6 h (<i>p</i> &lt; 0.05), accompanied by a decreasein total locomotor activity by 1666 wheel revolutions per day (<i>p</i> &lt; 0.05). Intranasal irisin administrationat any other time points of the projected circadian cycle did notinduce statistically significant phase shifts or changes in totallocomotor activity. Irisin did not alter the period of the circadianrhythm, regardless of the time of administration. The obtained resultsprovide experimental evidence for the role of endogenous irisinas a non-photic entraining factor for the circadian system, manifestingitself in the absence of the primary physiological zeitgeber, cyclicafferentation from retinal photoreceptors, in accordance with thedaily pattern and intensity of muscle activity within the muscle–brainfunctional axis.</p>

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Effect of the Myokine Irisin on Circadian Rhythm of Voluntary Locomotor Activity in Rats

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • A. N. Inyushkin,
  • S. I. Pavlenko,
  • T. S. Isakova,
  • A. T. Konashenkova,
  • E. M. Inyushkina,
  • A. A. Inyushkin

摘要

Abstract

The endogenous circadian oscillator, located in the mammaliansuprachiasmatic nucleus (SCN), generates its own rhythm, the periodof which typically does not precisely match the 24-h duration ofa day and hence requires entrainment with the geophysical circadianrhythm of the external world. One of the most important non-photicmechanisms of circadian clock entrainment is based on the information aboutthe pattern and intensity of physical activity. Within this mechanism,the role of the key molecular entrainment factor is attributed tothe myokine irisin. Meanwhile, irisin effects on behavioral circadian rhythmsremain unexplored. In the present study, the effects of triple intranasaladministration of irisin (0.5 µg) at various projected time pointsacross three consecutive circadian cycles (ZT 2, ZT 6, ZT 10, ZT14, ZT 18, and ZT 22) on the circadian rhythm of voluntary locomotoractivity in a running wheel under conditions of constant darknesswere investigated for the first time in experiments on male Wistar rats.Irisin administration at ZT 6 led to a statistically significantadvanced phase shift of the rhythm’s acrophase median by 0.6 h (p < 0.05), accompanied by a decreasein total locomotor activity by 1666 wheel revolutions per day (p < 0.05). Intranasal irisin administrationat any other time points of the projected circadian cycle did notinduce statistically significant phase shifts or changes in totallocomotor activity. Irisin did not alter the period of the circadianrhythm, regardless of the time of administration. The obtained resultsprovide experimental evidence for the role of endogenous irisinas a non-photic entraining factor for the circadian system, manifestingitself in the absence of the primary physiological zeitgeber, cyclicafferentation from retinal photoreceptors, in accordance with thedaily pattern and intensity of muscle activity within the muscle–brainfunctional axis.