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Abstract <p>Traumatic spinal cord and brain injuries are grave neurologicalconditions manifesting as a partial or total disruption of motor,sensory and autonomic functions, and in the case of traumatic braininjury, able to cause headaches and migraines, memory impairmentand other cognitive dysfunctions. Central nervous system injuriesevoke severe neuroinflammation characterized by an acute reactivityof microglia, macrophages and astrocytes, which leads to such long-termconsequences as local scarring, gliosis, and myelination defectsthat significantly affect brain development and function. Traceamines (TAs) can significantly contribute to the development ofneuroinflammation and hypoxia in spinal cord and brain injuries.Some individual TAs are able to influence reparative processes,e.g., 3-iodothyronamine is involved in the regulation of apoptosis,octopamine modulates the state of astrocytes, agmatine affects post-injuryexpression of trophic factors and neurogenesis. Moreover, such TAsas tyramine, tryptamine and β-phenylethylamine, as well as traceamine-associated receptors (TAARs), act as functional neuromodulatorsin the spinal cord and brain, and affect locomotor activity irrespectiveof the descending projections of classical monoamines. This reviewsummarizes the data on the role of various TAs and TAARs in thedevelopment of inflammatory processes during spinal cord and braininjuries, as well as addresses the prospects for their potentialtherapeutic applications.</p>

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Role of Trace Amines and Their Receptors in Neuroinflammation Development and Posttraumatic Spinal Cord and Brain Repair

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • A. D. Buglinina,
  • E. A. Romanyuk,
  • S. I. Milov,
  • A. A. Chesnokov,
  • D. S. Kalinina,
  • P. E. Musienko

摘要

Abstract

Traumatic spinal cord and brain injuries are grave neurologicalconditions manifesting as a partial or total disruption of motor,sensory and autonomic functions, and in the case of traumatic braininjury, able to cause headaches and migraines, memory impairmentand other cognitive dysfunctions. Central nervous system injuriesevoke severe neuroinflammation characterized by an acute reactivityof microglia, macrophages and astrocytes, which leads to such long-termconsequences as local scarring, gliosis, and myelination defectsthat significantly affect brain development and function. Traceamines (TAs) can significantly contribute to the development ofneuroinflammation and hypoxia in spinal cord and brain injuries.Some individual TAs are able to influence reparative processes,e.g., 3-iodothyronamine is involved in the regulation of apoptosis,octopamine modulates the state of astrocytes, agmatine affects post-injuryexpression of trophic factors and neurogenesis. Moreover, such TAsas tyramine, tryptamine and β-phenylethylamine, as well as traceamine-associated receptors (TAARs), act as functional neuromodulatorsin the spinal cord and brain, and affect locomotor activity irrespectiveof the descending projections of classical monoamines. This reviewsummarizes the data on the role of various TAs and TAARs in thedevelopment of inflammatory processes during spinal cord and braininjuries, as well as addresses the prospects for their potentialtherapeutic applications.