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Abstract <p>This study presents a comprehensive experimental and numerical investigation into the effects of Reynolds number (Re) on flow behavior in deterministic lateral displacement (DLD) devices. While conventional DLD operation typically occurs at low Reynolds numbers (Re &lt; 1) where viscous forces dominate, this research systematically explores the transition to higher Re regimes (0.04&#xa0;<InlineEquation ID="IEq1"> <EquationSource Format="TEX">\( \leqslant \)</EquationSource> <!--JAMT2570078Kovalev-m1--> </InlineEquation> Re <InlineEquation ID="IEq2"> <EquationSource Format="TEX">\( \leqslant \)</EquationSource> <!--JAMT2570078Kovalev-m2--> </InlineEquation> 66.7) to address the critical need for increased throughput in practical applications. The results demonstrate that increasing Reynolds number significantly alters flow profiles, with the emergence of recirculating vortices behind posts at Re <InlineEquation ID="IEq3"> <EquationSource Format="TEX">\( \approx \)</EquationSource> <!--JAMT2570078Kovalev-m3--> </InlineEquation> 50 and notable streamline narrowing, both factors reducing the effective critical diameter (<InlineEquation ID="IEq4"> <EquationSource Format="TEX">\({{D}_{c}}\)</EquationSource> <!--JAMT2570078Kovalev-m4--> </InlineEquation>) for particle separation. These findings reveal the limitations of traditional <InlineEquation ID="IEq5"> <EquationSource Format="TEX">\({{D}_{c}}\)</EquationSource> <!--JAMT2570078Kovalev-m5--> </InlineEquation> models, which remain accurate only in the low Re regime prior to vortex formation.</p>

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Reynolds-Number Effect on the Flow Structure in a Deterministic Lateral Displacement (DLD) Microfluidic Chip

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • A. V. Kovalev,
  • G. R. Turkiya,
  • M. V. Shestakov,
  • A. A. Yagodnitsyna

摘要

Abstract

This study presents a comprehensive experimental and numerical investigation into the effects of Reynolds number (Re) on flow behavior in deterministic lateral displacement (DLD) devices. While conventional DLD operation typically occurs at low Reynolds numbers (Re < 1) where viscous forces dominate, this research systematically explores the transition to higher Re regimes (0.04  \( \leqslant \) Re \( \leqslant \) 66.7) to address the critical need for increased throughput in practical applications. The results demonstrate that increasing Reynolds number significantly alters flow profiles, with the emergence of recirculating vortices behind posts at Re \( \approx \) 50 and notable streamline narrowing, both factors reducing the effective critical diameter ( \({{D}_{c}}\) ) for particle separation. These findings reveal the limitations of traditional \({{D}_{c}}\) models, which remain accurate only in the low Re regime prior to vortex formation.