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Abstract <p>Biodegradation of natural silk scaffolds made from gauze and satin fabrics was studied both in vitro and in vivo. Experiments were conducted using phosphate-buffered saline (PBS) and Fenton’s reagent to model degradation. Samples demonstrated high stability in the model of physiological conditions and varying degradation rates in oxidative stress. In vivo studies in rats showed good biocompatibility of the scaffolds and a gradual reduction in inflammatory responses. The findings highlight the potential of silk scaffolds for use in various areas of regenerative medicine.</p>

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In Vitro and In Vivo Biodegradation of Silk Fabric Scaffolds

  • 期刊论文

  • 发表日期：

    2025年1月31日

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  • I. I. Agapov,
  • E. I. Podbolotova,
  • L. A. Kirsanova,
  • N. V. Grudinin,
  • A. R. Pashutin,
  • O. I. Agapova,
  • A. E. Efimov,
  • A. V. Lyundup,
  • S. V. Gautier

摘要

Abstract

Biodegradation of natural silk scaffolds made from gauze and satin fabrics was studied both in vitro and in vivo. Experiments were conducted using phosphate-buffered saline (PBS) and Fenton’s reagent to model degradation. Samples demonstrated high stability in the model of physiological conditions and varying degradation rates in oxidative stress. In vivo studies in rats showed good biocompatibility of the scaffolds and a gradual reduction in inflammatory responses. The findings highlight the potential of silk scaffolds for use in various areas of regenerative medicine.