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Abstract <p>Radiation therapy is the cornerstone of the treatment of malignant tumors; however, its effectiveness is often limited by radioresistance and treatment-related toxicity. Peroxiredoxins, multifunctional proteins with antioxidant and chaperone activity, play a key role in maintaining redox homeostasis, regulating signaling pathways, and forming radioresistance. Due to these properties, they are considered as prognostic biomarkers and potential therapeutic targets for improving the effectiveness of antitumor radiation therapy. This review presents experimental strategies for overcoming radioresistance through peroxiredoxin modulation, including direct targeting, the use of exogenous proteins, engineered mutants, synthetic peptides, nanoplatforms, and combined effects on the peroxiredoxin–thioredoxin system.</p>

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Peroxiredoxins as Key Markers of Radioresistance and Potential Targets in Cancer Radiotherapy

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • E. E. Karmanova,
  • S. B. Parfenyuk,
  • O. V. Glushkova,
  • D. E. Burmistrov,
  • V. I. Novoselov,
  • M. G. Sharapov

摘要

Abstract

Radiation therapy is the cornerstone of the treatment of malignant tumors; however, its effectiveness is often limited by radioresistance and treatment-related toxicity. Peroxiredoxins, multifunctional proteins with antioxidant and chaperone activity, play a key role in maintaining redox homeostasis, regulating signaling pathways, and forming radioresistance. Due to these properties, they are considered as prognostic biomarkers and potential therapeutic targets for improving the effectiveness of antitumor radiation therapy. This review presents experimental strategies for overcoming radioresistance through peroxiredoxin modulation, including direct targeting, the use of exogenous proteins, engineered mutants, synthetic peptides, nanoplatforms, and combined effects on the peroxiredoxin–thioredoxin system.