Scholarlink

Abstract <p>L-threonine is an essential amino acid that is used in the agricultural, pharmaceutical, and food industries. In the present study, L-threonine production was significantly increased in a producer strain of <i>Escherichia coli</i> when grown on various carbon sources through an integrated approach to alter the metabolism of the strain. First, increasing the ability of <i>E. coli</i> to assimilate acetate through adaptive laboratory evolution has reduced its negative impact on the fermentation process and threonine production. Secondly, strengthening the deacetylation process at the later stages of the fermentation process made it possible to achieve a significant increase in the productivity of the strains.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Effect of Deacetylation on Threonine Production by a Threonine-Producing Strain of Escherichia coli

  • 期刊论文

  • 发表日期：

    2025年12月9日

查看全文
  • N. S. Plekhanova,
  • V. A. Livshits,
  • T. V. Khijniak,
  • M. S. Yurkova,
  • A. N. Fedorov

摘要

Abstract

L-threonine is an essential amino acid that is used in the agricultural, pharmaceutical, and food industries. In the present study, L-threonine production was significantly increased in a producer strain of Escherichia coli when grown on various carbon sources through an integrated approach to alter the metabolism of the strain. First, increasing the ability of E. coli to assimilate acetate through adaptive laboratory evolution has reduced its negative impact on the fermentation process and threonine production. Secondly, strengthening the deacetylation process at the later stages of the fermentation process made it possible to achieve a significant increase in the productivity of the strains.