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Abstract <p>Defensins are a class of antimicrobial peptides with antiviral, antibacterial, and biomodulatory activities [1, 2]. They present the effector molecules of the innate immune system and play an important role in host defence against pathogens, including enveloped or non-enveloped viruses, fungi and bacteria [3]. Defensins play an important role in virus invasion and infection. Here, we systematically describe the antiviral effects of defensins from four aspects: polypeptide structure, distribution in animals and antiviral mechanisms and applications emphasizing the potential of defensins as antiviral drugs.</p>

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The Other Side of Defensins: Review of Antiviral Activity of Defensins (Review)

  • 期刊论文

  • 发表日期：

    2025年6月15日

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  • K. Tao,
  • C. He,
  • Y. Zhu,
  • Z. Li,
  • D. Shao,
  • B. Li,
  • J. Wei,
  • Y. Qiu,
  • Z. Ma,
  • K. Liu

摘要

Abstract

Defensins are a class of antimicrobial peptides with antiviral, antibacterial, and biomodulatory activities [1, 2]. They present the effector molecules of the innate immune system and play an important role in host defence against pathogens, including enveloped or non-enveloped viruses, fungi and bacteria [3]. Defensins play an important role in virus invasion and infection. Here, we systematically describe the antiviral effects of defensins from four aspects: polypeptide structure, distribution in animals and antiviral mechanisms and applications emphasizing the potential of defensins as antiviral drugs.