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Abstract— <p>The marine fungal strain KMM 4719 was isolated from the sea cucumber <i>Apostichopus japonicus</i> and identified as <i>Penicillium polonicum</i> based on three molecular genetic markers: <i>ITS,</i> <i>BenA</i>, and <i>CaM</i>. 3-O-methylviridicatin was isolated from the ethyl acetate extract of the strain culture. 3-O-methylviridicatin has demonstrated cardioprotective activity for the first time, as well as urease inhibitory activity (IC<sub>50</sub> 97.3&#xa0;μM). In addition, 3-O-methylviridicatin at a concentration of 100 μM (25.1 μg/mL) inhibited the growth of the yeast-like fungus <i>Candida albicans</i> at 23.2%.</p>

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Biologically Active Quinolinone Alkaloid from the Marine Fungus Penicillium polonicum KMM 4719

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • S. S. Starnovskaya,
  • N. N. Kirichuk,
  • V. E. Chausova,
  • U. V. Khudyakova,
  • E. A. Chingizova,
  • A. R. Chingizov,
  • A. N. Yurchenko,
  • E. A. Yurchenko

摘要

Abstract—

The marine fungal strain KMM 4719 was isolated from the sea cucumber Apostichopus japonicus and identified as Penicillium polonicum based on three molecular genetic markers: ITS, BenA, and CaM. 3-O-methylviridicatin was isolated from the ethyl acetate extract of the strain culture. 3-O-methylviridicatin has demonstrated cardioprotective activity for the first time, as well as urease inhibitory activity (IC50 97.3 μM). In addition, 3-O-methylviridicatin at a concentration of 100 μM (25.1 μg/mL) inhibited the growth of the yeast-like fungus Candida albicans at 23.2%.