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Purpose <p>To assess second-year myopia progression in children after a 1-year randomised controlled trial of individualised ocular refraction customisation (IORC) spectacle lenses, customised to each eye's peripheral refraction.</p> Methods <p>A total of 161 children were randomised to wear IORC lenses with high (+4.50 D, IORC-H), medium (+3.50 D, IORC-M) or low (+2.50 D, IORC-L) myopic defocus or single-vision lenses (SV). In year 2, all children received IORC-H, forming the IORC-H1/H2/H3/H4 groups, respectively. An external SV (eSV, <i>n</i> = 42) group was matched to year 2 baseline parameters. Spherical equivalent refraction (SER) and axial length (AL) were measured every 6 months.</p> Results <p>Compared with the eSV group (12-month mean [SD] changes: SER −0.56 [0.44] D, AL 0.32 [0.16] mm), all IORC-H intervention groups demonstrated slower progression in year 2 (IORC-H1: −0.17 [0.37] D, 0.19 [0.14] mm; IORC-H2: −0.25 [0.41] D, 0.17 [0.16] mm; IORC-H3: −0.24 [0.36] D, 0.17 [0.14] mm; IORC-H4: −0.22 [0.40] D, 0.14 [0.17] mm; <i>p</i> &lt; 0.05), with no intergroup differences (<i>p</i> &gt; 0.05). Compared with the SV/eSV group, the IORC-H1 group presented 2-year reductions of 0.84 D and 0.38 mm in the SER and AL, respectively (<i>p</i> &lt; 0.001) and exhibited minimal progression during the initial 0–6 months (<i>p</i> &lt; 0.05), followed by constant progression over three subsequent 6-month intervals (<i>p</i> &gt; 0.05).</p> Conclusions <p>Switching to IORC-H in year 2 significantly reduced myopia progression and axial elongation. Maximal control efficacy occurred in the first 6 months, with sustained clinically meaningful effects thereafter.</p>

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Myopia control efficacy of individualised ocular refraction customisation spectacle lenses: A 2-year follow-up study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月11日

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  • Ji Kou,
  • Ye Wu,
  • Si Lei,
  • Ling Xiong,
  • Xiaohang Chen,
  • Longqian Liu

摘要

Purpose

To assess second-year myopia progression in children after a 1-year randomised controlled trial of individualised ocular refraction customisation (IORC) spectacle lenses, customised to each eye's peripheral refraction.

Methods

A total of 161 children were randomised to wear IORC lenses with high (+4.50 D, IORC-H), medium (+3.50 D, IORC-M) or low (+2.50 D, IORC-L) myopic defocus or single-vision lenses (SV). In year 2, all children received IORC-H, forming the IORC-H1/H2/H3/H4 groups, respectively. An external SV (eSV, n = 42) group was matched to year 2 baseline parameters. Spherical equivalent refraction (SER) and axial length (AL) were measured every 6 months.

Results

Compared with the eSV group (12-month mean [SD] changes: SER −0.56 [0.44] D, AL 0.32 [0.16] mm), all IORC-H intervention groups demonstrated slower progression in year 2 (IORC-H1: −0.17 [0.37] D, 0.19 [0.14] mm; IORC-H2: −0.25 [0.41] D, 0.17 [0.16] mm; IORC-H3: −0.24 [0.36] D, 0.17 [0.14] mm; IORC-H4: −0.22 [0.40] D, 0.14 [0.17] mm; p < 0.05), with no intergroup differences (p > 0.05). Compared with the SV/eSV group, the IORC-H1 group presented 2-year reductions of 0.84 D and 0.38 mm in the SER and AL, respectively (p < 0.001) and exhibited minimal progression during the initial 0–6 months (p < 0.05), followed by constant progression over three subsequent 6-month intervals (p > 0.05).

Conclusions

Switching to IORC-H in year 2 significantly reduced myopia progression and axial elongation. Maximal control efficacy occurred in the first 6 months, with sustained clinically meaningful effects thereafter.