Scholarlink

Purpose <p>Defocus Incorporated Soft Contact (DISC) lenses with +2.50 D myopic defocus reduced myopia progression by 25% in a previous randomised clinical trial (RCT). The current study aimed to evaluate if a stronger myopic defocus, +3.50 D with variable myopic defocus (DISC3.5plus), could slow myopia progression compared with single vision (SV) soft contact lenses in a 12-month RCT.</p> Methods <p>Conducted from December 2018 to January 2021, the current RCT randomly assigned myopic children to wear DISC3.5plus (<i>n</i> = 87) or SV (<i>n</i> = 80) lenses. Myopia progression and axial elongation were compared between the two groups. Analyses were performed for both enrolled and completed participants.</p> Results <p>For all enrolled participants, the DISC3.5plus group had significantly less myopia progression (mean difference: −0.15 ± 0.07 D, <i>p</i> = 0.02) and axial elongation (mean difference: 0.04 ± 0.02 D, <i>p</i> = 0.04) than the SV group at 6 months but not at 12 months (myopia progression: <i>p</i> = 0.11; axial elongation: <i>p</i> = 0.13). For completed participants, the DISC3.5plus group (<i>n</i> = 33) had reduced myopia progression at both 6 months (0.25 ± 0.07 D, <i>p</i> = 0.001) and 12 months (0.19 ± 0.09 D, <i>p</i> = 0.049) compared with the SV group (<i>n</i> = 40), but not in axial elongation (6 months: <i>p</i> = 0.16; 12 months: <i>p</i> = 0.32). In January 2020, the coronavirus pandemic disturbed contact lens-wearing patterns.</p> Conclusion <p>DISC3.5plus lenses significantly slowed myopia progression and axial elongation compared with SV lenses for all enrolled participants over 6 months. The pandemic hindered longer term efficacy follow-up and sample size; thus, further investigation with more participants is needed to confirm sustained treatment effects.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Myopia control using a modified optical defocus soft contact lens in schoolchildren—A 12-month randomised double masked control trial

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月1日

查看全文
  • Hanyu Zhang,
  • Ka Yan Leung,
  • Myra Leung,
  • Wing Chun Tang,
  • Chun Ki Wong,
  • Ka King Liu,
  • Dennis Yan Yin Tse,
  • Paul H. Lee,
  • Carly Siu Yin Lam

摘要

Purpose

Defocus Incorporated Soft Contact (DISC) lenses with +2.50 D myopic defocus reduced myopia progression by 25% in a previous randomised clinical trial (RCT). The current study aimed to evaluate if a stronger myopic defocus, +3.50 D with variable myopic defocus (DISC3.5plus), could slow myopia progression compared with single vision (SV) soft contact lenses in a 12-month RCT.

Methods

Conducted from December 2018 to January 2021, the current RCT randomly assigned myopic children to wear DISC3.5plus (n = 87) or SV (n = 80) lenses. Myopia progression and axial elongation were compared between the two groups. Analyses were performed for both enrolled and completed participants.

Results

For all enrolled participants, the DISC3.5plus group had significantly less myopia progression (mean difference: −0.15 ± 0.07 D, p = 0.02) and axial elongation (mean difference: 0.04 ± 0.02 D, p = 0.04) than the SV group at 6 months but not at 12 months (myopia progression: p = 0.11; axial elongation: p = 0.13). For completed participants, the DISC3.5plus group (n = 33) had reduced myopia progression at both 6 months (0.25 ± 0.07 D, p = 0.001) and 12 months (0.19 ± 0.09 D, p = 0.049) compared with the SV group (n = 40), but not in axial elongation (6 months: p = 0.16; 12 months: p = 0.32). In January 2020, the coronavirus pandemic disturbed contact lens-wearing patterns.

Conclusion

DISC3.5plus lenses significantly slowed myopia progression and axial elongation compared with SV lenses for all enrolled participants over 6 months. The pandemic hindered longer term efficacy follow-up and sample size; thus, further investigation with more participants is needed to confirm sustained treatment effects.