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<p>Housing-related stress, defined as concerns about not having a place to live, represents a significant correlate of substance use that warrants further investigation. In this cross-sectional analysis of 4358 adults from the national All of Us Research Program we examined associations between housing-related stress and substance use, accounting for demographic factors and mental health status in the United States. We determined that housing-related stress was significantly associated with increased odds of substance use (OR = 1.49, 95% CI 1.31–1.70). Males, racial and ethnic minorities, and individuals with poor mental health showed high substance use, while being better educated and married had a protective effect. The relationship between housing stress and substance use was amplified among those with poor mental health. Addressing housing instability should be integrated into comprehensive substance use prevention strategies. Given the universality of housing insecurity as a social determinant of health, these findings offer insights that can inform global public health strategies aimed at reducing substance use harms across diverse international contexts.</p>

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Housing-related stress and substance use in the United States: a cross-sectional analysis of All of Us Research Program data

  • 期刊论文

  • 发表日期：

    2025年12月14日

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  • Evans F. Kyei,
  • Samuel Akyirem,
  • Grace K. Kyei,
  • Rockson Ansong

摘要

Housing-related stress, defined as concerns about not having a place to live, represents a significant correlate of substance use that warrants further investigation. In this cross-sectional analysis of 4358 adults from the national All of Us Research Program we examined associations between housing-related stress and substance use, accounting for demographic factors and mental health status in the United States. We determined that housing-related stress was significantly associated with increased odds of substance use (OR = 1.49, 95% CI 1.31–1.70). Males, racial and ethnic minorities, and individuals with poor mental health showed high substance use, while being better educated and married had a protective effect. The relationship between housing stress and substance use was amplified among those with poor mental health. Addressing housing instability should be integrated into comprehensive substance use prevention strategies. Given the universality of housing insecurity as a social determinant of health, these findings offer insights that can inform global public health strategies aimed at reducing substance use harms across diverse international contexts.