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<p>Biological tissues undergo continuous, heterogeneous deformation, so that implantable biosensors must be soft, elastic and operationally stable in aqueous environments. Weak physiological signals are distorted at the biotic/abiotic interface, making in situ amplification essential for high-fidelity recording, yet existing devices cannot simultaneously provide strain-insensitive operation, aqueous stability and amplification. Here we introduce an integrated material–device–circuit strategy that enables the fabrication of elastic organic electrochemical transistor amplifiers with stable in vivo performance, including: a stretchable, aqueous-stable n-type polymer, P(bgTDPP-TVT-CN2) that maintains high performance under 100% strain; a self-assembled monolayer ensures robust interlayer adhesion in strained, aqueous conditions; a complementary p–n organic electrochemical transistor architecture that counterbalances strain-induced current variations. The resulting amplifiers maintain high gain under &gt;50% deformation and directly capture and amplify in vivo biosignals with substantially improved signal-to-noise ratios, establishing a route to mechanically resilient, high-fidelity bioelectronic interfaces.</p>

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Elastic in vivo biosignal amplifiers based on strain-insensitive material and circuit design

  • 期刊论文

  • 发表日期：

    2026年7月30日

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  • Wenxi Sun,
  • Xiran Pan,
  • Wanqiong Yuan,
  • Weiwei Xia,
  • Xun Lei,
  • Peiyun Li,
  • Chengyu Wang,
  • Biqin Yang,
  • Yuting Zheng,
  • Xiao-Yan Zhang,
  • Simin Liang,
  • Xiu Wang,
  • Bingqi Wang,
  • Yuying Wu,
  • Pan Gu,
  • Kai Liu,
  • Hanqiang Ouyang,
  • Chenxin Zhu,
  • Zhi Zhang,
  • Ting Lei

摘要

Biological tissues undergo continuous, heterogeneous deformation, so that implantable biosensors must be soft, elastic and operationally stable in aqueous environments. Weak physiological signals are distorted at the biotic/abiotic interface, making in situ amplification essential for high-fidelity recording, yet existing devices cannot simultaneously provide strain-insensitive operation, aqueous stability and amplification. Here we introduce an integrated material–device–circuit strategy that enables the fabrication of elastic organic electrochemical transistor amplifiers with stable in vivo performance, including: a stretchable, aqueous-stable n-type polymer, P(bgTDPP-TVT-CN2) that maintains high performance under 100% strain; a self-assembled monolayer ensures robust interlayer adhesion in strained, aqueous conditions; a complementary p–n organic electrochemical transistor architecture that counterbalances strain-induced current variations. The resulting amplifiers maintain high gain under >50% deformation and directly capture and amplify in vivo biosignals with substantially improved signal-to-noise ratios, establishing a route to mechanically resilient, high-fidelity bioelectronic interfaces.