<p>Exhaled breath condensate (EBC) offers a non-invasive window into respiratory and systemic metabolism, yet wearable EBC systems are constrained by unstable moisture harvesting, short sensor lifetimes in humidity and battery dependence. Here we present EBClite, a battery-free smart mask for multiday EBC biomarker monitoring, using lactate as a model analyte. The platform integrates a regenerable antidrying porous hydrogel that achieves sustained and reactivatable breath condensation over several days, extending operational lifetime while reducing material cost. EBClite further incorporates a long-term stable electrochemical lactate sensor and an ultrathin quasi-two-dimensional perovskite solar cell with a power-to-weight ratio of 10 W g<sup>−1</sup> and a power conversion efficiency exceeding 30% under ambient indoor illumination, enabling autonomous operation across diverse lighting conditions. Human studies demonstrate strong correlations between EBC and blood lactate levels during exercise and carbohydrate intake, enabling real-time tracking of metabolic fluctuations. EBClite provides a sustainable, user-friendly platform for continuous respiratory and metabolic monitoring.</p>

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A battery-free smart mask for long-term exhaled breath biochemical sensing

  • Wenzheng Heng,
  • Christoph Putz,
  • Wenying Tang,
  • Jihong Min,
  • Lukas E. Lehner,
  • Stepan Demchyshyn,
  • Gwangmook Kim,
  • Canran Wang,
  • Bekele Hailegnaw,
  • Elias Rippatha,
  • Markus Scharber,
  • Moon-Ju Kim,
  • Yonglin Chen,
  • Zhiyong Fan,
  • Martin Kaltenbrunner,
  • Wei Gao

摘要

Exhaled breath condensate (EBC) offers a non-invasive window into respiratory and systemic metabolism, yet wearable EBC systems are constrained by unstable moisture harvesting, short sensor lifetimes in humidity and battery dependence. Here we present EBClite, a battery-free smart mask for multiday EBC biomarker monitoring, using lactate as a model analyte. The platform integrates a regenerable antidrying porous hydrogel that achieves sustained and reactivatable breath condensation over several days, extending operational lifetime while reducing material cost. EBClite further incorporates a long-term stable electrochemical lactate sensor and an ultrathin quasi-two-dimensional perovskite solar cell with a power-to-weight ratio of 10 W g−1 and a power conversion efficiency exceeding 30% under ambient indoor illumination, enabling autonomous operation across diverse lighting conditions. Human studies demonstrate strong correlations between EBC and blood lactate levels during exercise and carbohydrate intake, enabling real-time tracking of metabolic fluctuations. EBClite provides a sustainable, user-friendly platform for continuous respiratory and metabolic monitoring.