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<p>Myocardial infarction (MI) leads to cardiomyocytes (CMs) death and impaired cardiac function, primarily due to excessive reactive oxygen species and inflammation. Carbon monoxide (CO) exhibits dose-dependent cardioprotective effects but faces challenges in achieving controlled local delivery. Herein, a photoactivable CO-releasing hydrogel based cardiac patch (pCO patch) for controlled CO delivery to repair cardiac function post-MI. Additionally, the pCO patch integrates a self-regulating system combining a wireless LED module and gas detection module to regulate CO release within the predetermined dose range. In vitro, the pCO patch releases CO in a controlled behavior by adjusting the LED light, effectively protecting CMs from the oxidative stress-induced damage and preventing apoptosis associated with continuous CO release. Additionally, the pCO patch was confirmed to reduce inflammation levels and thereby improve damage cardiac functions in a mouse MI module, highlighting its potential as a promising CO delivery approach for cardiac repair post-MI.</p>

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Photoactivable CO-releasing hydrogel based cardiac patch with a self-regulation system for cardiac repair post-myocardial infarction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月25日

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  • Gangfeng Li,
  • Haomiao Bai,
  • Dawei Zhao,
  • Jian Song,
  • Jia Li,
  • Peng Li,
  • Tengjiao Wang

摘要

Myocardial infarction (MI) leads to cardiomyocytes (CMs) death and impaired cardiac function, primarily due to excessive reactive oxygen species and inflammation. Carbon monoxide (CO) exhibits dose-dependent cardioprotective effects but faces challenges in achieving controlled local delivery. Herein, a photoactivable CO-releasing hydrogel based cardiac patch (pCO patch) for controlled CO delivery to repair cardiac function post-MI. Additionally, the pCO patch integrates a self-regulating system combining a wireless LED module and gas detection module to regulate CO release within the predetermined dose range. In vitro, the pCO patch releases CO in a controlled behavior by adjusting the LED light, effectively protecting CMs from the oxidative stress-induced damage and preventing apoptosis associated with continuous CO release. Additionally, the pCO patch was confirmed to reduce inflammation levels and thereby improve damage cardiac functions in a mouse MI module, highlighting its potential as a promising CO delivery approach for cardiac repair post-MI.