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<p>Medical coding is essential for healthcare operations yet remains predominantly manual, error-prone (up to 20%), and costly (up to $18.2 billion annually). Although large language models (LLMs) have shown promise in natural language processing, their application to medical coding has produced limited accuracy. In this study, we evaluated whether fine-tuning LLMs with specialized ICD-10 knowledge can automate code generation across clinical documentation. We adopted a two-phase approach: initial fine-tuning using 74,260 ICD-10 code–description pairs, followed by enhanced training to address linguistic and lexical variations. Evaluations using a proprietary model (GPT-4o mini) on a cloud platform and an open-source model (Llama) on local GPUs demonstrated that initial fine-tuning increased exact matching from &lt;1% to 97%, while enhanced fine-tuning further improved performance in complex scenarios, with real-world clinical notes achieving 69.20% exact match and 87.16% category match. These findings indicate that domain-specific fine-tuned LLMs can reduce manual burdens and improve reliability.</p>

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Enhancing medical coding efficiency through domain-specific fine-tuned large language models

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月1日

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  • Zhen Hou,
  • Hao Liu,
  • Jiang Bian,
  • Xing He,
  • Yan Zhuang

摘要

Medical coding is essential for healthcare operations yet remains predominantly manual, error-prone (up to 20%), and costly (up to $18.2 billion annually). Although large language models (LLMs) have shown promise in natural language processing, their application to medical coding has produced limited accuracy. In this study, we evaluated whether fine-tuning LLMs with specialized ICD-10 knowledge can automate code generation across clinical documentation. We adopted a two-phase approach: initial fine-tuning using 74,260 ICD-10 code–description pairs, followed by enhanced training to address linguistic and lexical variations. Evaluations using a proprietary model (GPT-4o mini) on a cloud platform and an open-source model (Llama) on local GPUs demonstrated that initial fine-tuning increased exact matching from <1% to 97%, while enhanced fine-tuning further improved performance in complex scenarios, with real-world clinical notes achieving 69.20% exact match and 87.16% category match. These findings indicate that domain-specific fine-tuned LLMs can reduce manual burdens and improve reliability.