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<p>Evidence on differences in dementia risk by sex and gender is mixed. We aimed to compare lifetime dementia risk by sex/gender among Asian American and non-Latino White adults aged 60 and older. We included Chinese (<i>n</i> = 6415), Filipino (<i>n</i> = 5020), Japanese (<i>n</i> = 3314), South Asian (<i>n</i> = 1061), and non-Latino White (<i>n</i> = 143,667) Kaiser Permanente Northern California members aged ≥60 years who completed health surveys (2002–2020) and were dementia-free at baseline. We estimated cause-specific cumulative dementia incidence from age 60 to 95 years (i.e., lifetime dementia risk, treating death as a competing event) and evaluated sex/gender differences. Lifetime dementia risk was higher among women in all groups, ranging from 7 (95% CI: 2–13) percentage points higher for Japanese women vs. men to 21 (8–38) percentage points higher for South Asian women vs. men. Variations of sex/gender differences across racial and ethnic groups are potentially driven by dementia-free mortality and social and structural factors.</p>

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Sex/gender differences in lifetime dementia risk among Asian American and White older adults

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月13日

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  • L. Paloma Rojas-Saunero,
  • Yingyan Wu,
  • Yixuan Zhou,
  • Eleanor Hayes-Larson,
  • Gilbert C. Gee,
  • Ron Brookmeyer,
  • Holly Elser,
  • Alexander Ivan B. Posis,
  • Alka M. Kanaya,
  • Rachel A. Whitmer,
  • Paola Gilsanz,
  • Elizabeth Rose Mayeda

摘要

Evidence on differences in dementia risk by sex and gender is mixed. We aimed to compare lifetime dementia risk by sex/gender among Asian American and non-Latino White adults aged 60 and older. We included Chinese (n = 6415), Filipino (n = 5020), Japanese (n = 3314), South Asian (n = 1061), and non-Latino White (n = 143,667) Kaiser Permanente Northern California members aged ≥60 years who completed health surveys (2002–2020) and were dementia-free at baseline. We estimated cause-specific cumulative dementia incidence from age 60 to 95 years (i.e., lifetime dementia risk, treating death as a competing event) and evaluated sex/gender differences. Lifetime dementia risk was higher among women in all groups, ranging from 7 (95% CI: 2–13) percentage points higher for Japanese women vs. men to 21 (8–38) percentage points higher for South Asian women vs. men. Variations of sex/gender differences across racial and ethnic groups are potentially driven by dementia-free mortality and social and structural factors.