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<p>The aims of this study were to determine the mediating role of marijuana use in the association between ACEs and SCD and the potential differences by race/ethnicity and sexual orientation. Data were obtained from the 2023 Behavioral Risk Factor Surveillance System (<i>N</i> = 21,132). Mediation analysis was used to determine the mediating role of marijuana use between ACEs and SCD. Adjusted analyses controlled for sociodemographic and health status confounders. Overall, there was a direct association between ACEs and marijuana use (<i>β</i> = 0.300, <i>p</i> &lt; 0.001), marijuana use and SCD (<i>β</i> = 0.003, <i>p</i> &lt; 0.001); and between ACEs and SCD (<i>β</i> = 0.016, <i>p</i> &lt; 0.001). Marijuana use mediated the association between ACEs and SCD in the overall population (<i>β</i> = 0.001, <i>p</i> &lt; 0.001). Specifically, marijuana use mediated the association between ACEs and SCD among heterosexual (<i>β</i> = 0.001, <i>p</i> = 0.001) and White (<i>β</i> = 0.001, <i>p</i> &lt; 0.001) respondents. Future research should examine additional pathways between ACEs and SCD, especially for racial/ethnic and sexual minoritized populations.</p>

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Adverse childhood experiences, marijuana use and subjective cognitive decline by race/ethnicity and sexual orientation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月10日

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  • Monique J. Brown,
  • Josie Zhang

摘要

The aims of this study were to determine the mediating role of marijuana use in the association between ACEs and SCD and the potential differences by race/ethnicity and sexual orientation. Data were obtained from the 2023 Behavioral Risk Factor Surveillance System (N = 21,132). Mediation analysis was used to determine the mediating role of marijuana use between ACEs and SCD. Adjusted analyses controlled for sociodemographic and health status confounders. Overall, there was a direct association between ACEs and marijuana use (β = 0.300, p < 0.001), marijuana use and SCD (β = 0.003, p < 0.001); and between ACEs and SCD (β = 0.016, p < 0.001). Marijuana use mediated the association between ACEs and SCD in the overall population (β = 0.001, p < 0.001). Specifically, marijuana use mediated the association between ACEs and SCD among heterosexual (β = 0.001, p = 0.001) and White (β = 0.001, p < 0.001) respondents. Future research should examine additional pathways between ACEs and SCD, especially for racial/ethnic and sexual minoritized populations.