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<p>The Asian Cohort for Alzheimer’s Disease (ACAD) study is a collaborative investigation of genetic and non-genetic risk factors for AD among Asian Americans and Canadians. Harmonization of diagnostic procedures across recruiting sites will be key to the dataset’s efficacy.</p><p>Forty-two participants who completed the consensus process across seven ACAD recruiting sites were re-reviewed by two further impartial raters. Cohen’s Kappa coefficient was used to evaluate inter-rater agreement. The findings reveal the highest level of observed agreement at 88% and a Cohen’s Kappa of 0.835, among site consensus participants and two levels of external review, affirming the reliability of our protocol. ACAD has developed a data collection and diagnostic process that allows consistency among sites that serve Asians speaking Korean, Chinese, and Vietnamese languages.</p>

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High inter-rater reliability in consensus diagnoses and overall assessment in the Asian Cohort for Alzheimer’s Disease Study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月30日

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  • Yara Alkhodair,
  • Ging-Yuek R. Hsiung,
  • Boon Lead Tee,
  • Pei-Chuan Ho,
  • Phoenix Au Yeung,
  • Wai Haung Yu,
  • Guerry M. Peavy,
  • Victor W. Henderson,
  • Yun-Beom Choi,
  • Clara Li,
  • Dolly Reyes-Dumeyer,
  • Haeok Lee,
  • Walter A. Kukull,
  • Howard H. Feldman,
  • Yian Gu,
  • Pei-Chuan Ho,
  • Ging-Yuek Robin Hsiung,
  • Lorene Leung,
  • Collin Liu,
  • Richard Mayeux,
  • Guerry M. Peavy,
  • Boon Lead Tee,
  • Ellen C. Wong,
  • Hyun-sik Yang,
  • Jennifer S. Yokoyama,
  • Gyungah R. Jun,
  • Van M. Ta Park,
  • Helena C. Chui,
  • Li-San Wang,
  • Tiffany W. Chow,
  • Tatiana Foroud,
  • Joshua D. Grill,
  • Maureen Kirsch,
  • Wan-Ping Lee,
  • Mingyao Li,
  • Van M. Ta Park,
  • Gerard D. Schellenberg,
  • Mina Torres,
  • Marian Tzuang,
  • Badri N. Vardarajan,
  • Rohit Varma,
  • Eugene Yau

摘要

The Asian Cohort for Alzheimer’s Disease (ACAD) study is a collaborative investigation of genetic and non-genetic risk factors for AD among Asian Americans and Canadians. Harmonization of diagnostic procedures across recruiting sites will be key to the dataset’s efficacy.

Forty-two participants who completed the consensus process across seven ACAD recruiting sites were re-reviewed by two further impartial raters. Cohen’s Kappa coefficient was used to evaluate inter-rater agreement. The findings reveal the highest level of observed agreement at 88% and a Cohen’s Kappa of 0.835, among site consensus participants and two levels of external review, affirming the reliability of our protocol. ACAD has developed a data collection and diagnostic process that allows consistency among sites that serve Asians speaking Korean, Chinese, and Vietnamese languages.