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<p>Molecular glues are small molecules that induce ternary complexes between a protein of interest and a partner protein, creating therapeutic mechanisms distinct from traditional inhibitors. This minireview examines binding-site architectures of clinically tested molecular glues and extends these insights to ubiquitin-family partner proteins. Structural analysis suggests recurring recognition features, while emerging computational methods may accelerate discovery and optimization of ubiquitin-directed glues for therapeutic applications.</p>

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Ubiquitin family as novel protein partners for molecular glues

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年8月4日

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  • Laura Silvian

摘要

Molecular glues are small molecules that induce ternary complexes between a protein of interest and a partner protein, creating therapeutic mechanisms distinct from traditional inhibitors. This minireview examines binding-site architectures of clinically tested molecular glues and extends these insights to ubiquitin-family partner proteins. Structural analysis suggests recurring recognition features, while emerging computational methods may accelerate discovery and optimization of ubiquitin-directed glues for therapeutic applications.