Scholarlink

<p>Osteoarthritis (OA) is a leading cause of chronic pain and disability, and lacks disease-modifying therapies. Unlike conventional hydrogels, which suffer from poor mechanical robustness and limited retention, cryogels overcome existing limitations through their interconnected pore architecture, shape-memory behavior, and fatigue-resistant mechanics. Here, we review how cryogels are being engineered as platforms for stem cell delivery, bioactive molecule release, localized gene activation, and immunomodulation, and discuss key translation challenges.</p><p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Cryogel-based therapeutic platforms for disease modification in osteoarthritis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月1日

查看全文
  • Jewelia A. Durant,
  • Maria Eduarda Torres Gouveia,
  • Aleyna E. La Croix,
  • Adithya R. Puninchittaya,
  • Katherine R. Hixon

摘要

Osteoarthritis (OA) is a leading cause of chronic pain and disability, and lacks disease-modifying therapies. Unlike conventional hydrogels, which suffer from poor mechanical robustness and limited retention, cryogels overcome existing limitations through their interconnected pore architecture, shape-memory behavior, and fatigue-resistant mechanics. Here, we review how cryogels are being engineered as platforms for stem cell delivery, bioactive molecule release, localized gene activation, and immunomodulation, and discuss key translation challenges.