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<p>Peptide-based strategies offer promising solutions to overcome the complex, multi-tissue barriers of osteoarthritis. Their tunability, specificity, and versatility enable targeted drug delivery to cartilage, synovium, and subchondral bone, while some therapeutic peptides provide intrinsic anti-inflammatory, regenerative, or analgesic effects. Advances in peptide design, stability engineering, and in silico screening, alongside emerging human joint-on-chip models, are accelerating the development of targeted, stable, multi-tissue OA therapies.</p>

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Peptide-based targeted drug delivery strategies for osteoarthritis treatment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月9日

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  • Bill Hakim,
  • Hengli Zhang,
  • Andrew Selvadoss,
  • Ambika Bajpayee

摘要

Peptide-based strategies offer promising solutions to overcome the complex, multi-tissue barriers of osteoarthritis. Their tunability, specificity, and versatility enable targeted drug delivery to cartilage, synovium, and subchondral bone, while some therapeutic peptides provide intrinsic anti-inflammatory, regenerative, or analgesic effects. Advances in peptide design, stability engineering, and in silico screening, alongside emerging human joint-on-chip models, are accelerating the development of targeted, stable, multi-tissue OA therapies.