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<p>Macrophages strongly influence cancer progression through their adaptable phenotypes and responses to mechanical and biochemical cues. Their abundance across tumors and links to poor outcomes drive interest in macrophage-targeted therapies. This review highlights macrophage mechanobiology, key behaviors, and the potential of engineered macrophages, using genetic (CAR) or non-genetic “Trojan horse” and “backpacking” strategies, to deliver therapies and reshape the immunosuppressive tumor microenvironment.</p>

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Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月2日

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  • Anton Block,
  • Xiaoya Liu,
  • Daniel Zhang,
  • Kolade Adebowale

摘要

Macrophages strongly influence cancer progression through their adaptable phenotypes and responses to mechanical and biochemical cues. Their abundance across tumors and links to poor outcomes drive interest in macrophage-targeted therapies. This review highlights macrophage mechanobiology, key behaviors, and the potential of engineered macrophages, using genetic (CAR) or non-genetic “Trojan horse” and “backpacking” strategies, to deliver therapies and reshape the immunosuppressive tumor microenvironment.