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<p>In this review, we systematically categorize diverse organoid engineering strategies—including cellular programming, material engineering, and platform- or system-level innovations—according to their impact on reproducibility and scalability, and highlight representative applications and emerging directions. By reframing organoid generation as a manufacturing process, these technological advances pave the way toward standardized and high-fidelity organoid production for both fundamental research and translational applications.</p>

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From organoid culture to manufacturing: technologies for reproducible and scalable organoid production

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月2日

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  • Dohui Kim,
  • Jaeseung Youn,
  • Juhyeok Kim,
  • Jeongmin Lee,
  • Jangwon Yoon,
  • Dong Sung Kim

摘要

In this review, we systematically categorize diverse organoid engineering strategies—including cellular programming, material engineering, and platform- or system-level innovations—according to their impact on reproducibility and scalability, and highlight representative applications and emerging directions. By reframing organoid generation as a manufacturing process, these technological advances pave the way toward standardized and high-fidelity organoid production for both fundamental research and translational applications.