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<p>Sonobiopsy uses focused ultrasound to enrich circulating biomarkers from ultrasound-targeted disease regions, enabling sensitive and spatially targeted molecular diagnosis through liquid biopsy. Since the concept of integrating ultrasound with liquid biopsy was introduced in 2009, the field has advanced to incorporate various ultrasound modalities for applications across a range of diseases. To drive clinical translation of sonobiopsy, it is essential to optimize focused ultrasound techniques, enhance biomarker analysis, and elucidate underlying mechanisms.</p>

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Sonobiopsy for sensitive and spatially targeted molecular diagnosis through integrating ultrasound with liquid biopsy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月3日

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  • Jinyun Yuan,
  • Hong Chen

摘要

Sonobiopsy uses focused ultrasound to enrich circulating biomarkers from ultrasound-targeted disease regions, enabling sensitive and spatially targeted molecular diagnosis through liquid biopsy. Since the concept of integrating ultrasound with liquid biopsy was introduced in 2009, the field has advanced to incorporate various ultrasound modalities for applications across a range of diseases. To drive clinical translation of sonobiopsy, it is essential to optimize focused ultrasound techniques, enhance biomarker analysis, and elucidate underlying mechanisms.