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<p>Since 2024, Cuba has suffered concurrent outbreaks of arboviruses, including Oropouche virus (OROV) and dengue virus. Here, to assess population-level susceptibility, 670 age- and sex-matched serum samples from La Habana were analysed, comparing age- and sex-matched pre-OROV outbreak (2020–2021) and post-OROV outbreak (2025) cohorts. OROV-specific IgG detection increased from 0.9% to 13.4%. Age-adjusted estimates suggested an overall seroprevalence of 16.7%, indicating that 2,257-fold more infections had occurred than were detected by early 2025. OROV seroprevalence declined with age, consistent with recent viral introduction into a naive population. By contrast, the detection rate of dengue-virus-specific IgG was high in both cohorts (63.3–78.5%). Detection of OROV-specific IgM in 1.8% of samples from 2025 confirmed ongoing transmission. Overall, these data indicate sustained co-circulation of multiple arboviruses in Cuba, underscoring the urgent need for surveillance and local vaccine development.</p>

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Seroprevalence of Oropouche virus following the 2024–2025 outbreak in Cuba

  • 期刊论文

  • 发表日期：

    2026年6月1日

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  • Dagmar García-Rivera,
  • Carlo Fischer,
  • Liliana López León,
  • Nadine Olk,
  • Marta Piche-Ovares,
  • Laura Rodríguez-Noda,
  • Beatriz Paredes-Moreno,
  • Stefan Flasche,
  • Daniel G. Rivera,
  • Vicente Verez-Bencomo,
  • Jan Felix Drexler

摘要

Since 2024, Cuba has suffered concurrent outbreaks of arboviruses, including Oropouche virus (OROV) and dengue virus. Here, to assess population-level susceptibility, 670 age- and sex-matched serum samples from La Habana were analysed, comparing age- and sex-matched pre-OROV outbreak (2020–2021) and post-OROV outbreak (2025) cohorts. OROV-specific IgG detection increased from 0.9% to 13.4%. Age-adjusted estimates suggested an overall seroprevalence of 16.7%, indicating that 2,257-fold more infections had occurred than were detected by early 2025. OROV seroprevalence declined with age, consistent with recent viral introduction into a naive population. By contrast, the detection rate of dengue-virus-specific IgG was high in both cohorts (63.3–78.5%). Detection of OROV-specific IgM in 1.8% of samples from 2025 confirmed ongoing transmission. Overall, these data indicate sustained co-circulation of multiple arboviruses in Cuba, underscoring the urgent need for surveillance and local vaccine development.